(R)-(-)-2-(4-ISOBUTYLPHENYL)-PROPIONIC ACID
(R)-(-)-IBUPROFEN
CAS: 51146-57-7
Molecular Formula: C13H18O2
(R)-(-)-2-(4-ISOBUTYLPHENYL)-PROPIONIC ACID - Names and Identifiers
(R)-(-)-2-(4-ISOBUTYLPHENYL)-PROPIONIC ACID - Physico-chemical Properties
| Molecular Formula | C13H18O2 |
| Molar Mass | 206.28 |
| Density | 1.0176 (rough estimate) |
| Melting Point | 41-42°C |
| Boling Point | 305.14°C (rough estimate) |
| Water Solubility | 369.3mg/L(25 ºC) |
| Solubility | Soluble in methanol, 0.1 M NaOH, dichloromethane, and ethyl acetate. |
| Appearance | Shape White crystalline powder, color Colourless to Pale Beige Oil |
| pKa | 4.41±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Refractive Index | 1.5290 (estimate) |
| MDL | MFCD00069290 |
| Physical and Chemical Properties | Bioactive (R)-(-)-Ibuprofen is a Ibuprofen R-type isomer, which has no effect on COX and can inhibit the activation of NF-κB. (R)-(-)-Ibuprofen has anti-inflammatory and analgesic effects. |
| Use | Use Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID); the activity is mainly present in the (S)-isomer. |
(R)-(-)-2-(4-ISOBUTYLPHENYL)-PROPIONIC ACID - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| HS Code | 29155090 |
(R)-(-)-2-(4-ISOBUTYLPHENYL)-PROPIONIC ACID - Introduction
(R)-Ibuprofen are ibuprofen low-activity enantiomers.
Last Update：2022-10-16 17:30:56
(R)-(-)-2-(4-ISOBUTYLPHENYL)-PROPIONIC ACID - Nature
| Solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) |
Last Update：2024-04-10 22:29:15
(R)-(-)-2-(4-ISOBUTYLPHENYL)-PROPIONIC ACID - Uses and synthesis methods
Target
NF-κ B
in vitro studies
(R)-(-)-Ibuprofen is the R enantiomer of Ibuprofen, with no inhibitory effect on COX, but is involved in pathways of lipid metabolism and is incorporated into triglycerides along with endogenous fatty acids. (R)-(-)-Ibuprofen (1 μM) significantly reduces NF-κ B activation and completely prevents NF-κ B induction at 10 μM. (R)-(-)-Ibuprofen inhibits NF-κ B luciferase activity with an IC 50 of 121.8 μM, weaker than that of S( )-ibuprofen (IC 50 , 61.7 μM). Furthermore, (R)-(-)-Ibuprofen (10 mM) has no effect on HSF.
Last Update：2024-04-10 22:29:15
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Product Name: (R)-(-)-Ibuprofen Visit Supplier Webpage Request for quotationCAS: 51146-57-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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